Associate Professor Thomas Cox's research investigates how the matrix's biochemical and biomechanical properties modulate resident cell behaviour, driving pathological progression.
By employing multiple approaches such as new imaging technologies, matrix cataloguing, and in vitro microenvironment recapitulation, research from his lab sheds light on the factors that shape tumour development, evolution, and cellular heterogeneity. This knowledge can enable a better understanding of tumour response to various therapies.
The non-selective depletion of the matrix has yielded paradoxical results, often accelerating progression. The research has shown that more nuanced approaches to normalising biochemistry and biomechanics, rather than depleting the matrix, result in favourable outcomes. Consequently, co-targeting the changing matrix in cancer and the cellular response to the remodelled tumour matrix offers powerful strategies to improve therapy outcomes for patients.
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A/Prof Thomas Cox is a renowned cancer cell biologist, specialising in extracellular matrix and matrix remodelling in solid tumour progression and metastasis. With a Ph.D. from the University of Durham and Postdoc positions at prestigious institutes, he has established a creative research program that integrates matrix biology with precision oncology.
