Breast cancer is the most commonly occurring cancer in women. Over the last decade, research has made substantial progress in understanding the complexity of breast cancer, particularly focusing on tumor heterogeneity and the tumor microenvironment.
Advanced technologies have played a crucial role in these advancements. Next-generation sequencing (NGS) platforms have revolutionised genomic research by allowing high-throughput sequencing, providing detailed insights into genetic mutations, variations, and overall cancer genomics.
The latest advancements in single-cell technologies have enabled researchers to examine gene expression profiles at the individual cell level, revealing the diverse cellular landscape within a tumor. However, the emergence of spatial technologies introduces an additional dimension of spatial information, providing enhanced insights into the cellular diversity of human breast cancer within a spatial context.
Dr Chen's main research interests are gene expression, alternative splicing, single-cell and spatial-omics analysis, as well as the application of these cutting-edge technologies in cancer research. His laboratory has extensive experience and strong expertise in differential gene/transcript expression and pathways analysis in bulk and single-cell RNA-seq experiments. Over the last decade, Dr Chen and his group has been working closely with cancer researchers, especially the Breast Cancer Lab at WEHI, focusing on cancer genesis and the identification of cancer cell-of-origin.
